• Eisa A, Dey S, Ignatious A, Nofal W, Hess RA, Kurokawa M, Kline D, Vijayaraghavan S. The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for male fertility. Andrology. 2021 Jan;9(1):312-328. doi: 10.1111/andr.12865. Epub 2020 Aug 5. PubMed PMID: 32657535; PubMed Central PMCID: PMC8356477.
• Dey S, Eisa A, Kline D, Wagner FF, Abeysirigunawardena S, Vijayaraghavan S. Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs. FASEB J. 2020 Jan;34(1):1247-1269. doi: 10.1096/fj.201902163R. Epub 2019 Nov 29. PubMed PMID: 31914663; PubMed Central PMCID: PMC7539848
• Dey S, Brothag C, Vijayaraghavan S. Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals. Front Cell Dev Biol. 2019;7:341. doi: 10.3389/fcell.2019.00341. eCollection 2019. Review. PubMed PMID: 31921853; PubMed Central PMCID: PMC6930163
• Eisa AA, De S, Detwiler A, Gilker E, Ignatious AC, Vijayaraghavan S, Kline D. YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation. BMC Dev Biol. 2019 Oct 22;19(1):20. doi: 10.1186/s12861-019-0200-1. PubMed PMID: 31640562; PubMed Central PMCID: PMC6805688.
• Freitas MJ, Silva JV, Brothag C, Regadas-Correia B, Fardilha M, Vijayaraghavan S. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Mol Hum Reprod. 2019 Apr 1;25(4):171-183. doi: 10.1093/molehr/gaz009. PubMed PMID: 30824926; PubMed Central PMCID: PMC6440577.
• Dudiki T, Joudeh N, Sinha N, Goswami S, Eisa A, Kline D, Vijayaraghavan S. The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility†. Biol Reprod. 2019 Mar 1;100(3):721-736. doi: 10.1093/biolre/ioy225. PubMed PMID: 30379985; PubMed Central PMCID: PMC6437266.
• Goswami S, Korrodi-Gregório L, Sinha N, Bhutada S, Bhattacharjee R, Kline D, Vijayaraghavan S. Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation. J Cell Physiol. 2019 Mar;234(3):3105-3118. doi: 10.1002/jcp.27130. Epub 2018 Aug 25. PubMed PMID: 30144392; PubMed Central PMCID: PMC6855402.
• Dey S, Goswami S, Eisa A, Bhattacharjee R, Brothag C, Kline D, Vijayaraghavan S. Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa. J Cell Physiol. 2018 Sep;233(9):7239-7252. doi: 10.1002/jcp.26557. Epub 2018 Mar 25. PubMed PMID: 29574946.

• Goswami S, Korrodi-Gregório L, Sinha N, Bhutada S, Bhattacharjee R, Kline D, Vijayaraghavan S. Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation. J Cell Physiol. 2018 Aug 25. doi: 10.1002/jcp.27130. [Epub ahead of print] PubMed PMID: 30144392.

• Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, KlineD, Vijayaraghavan S. Isoform specific requirement for GSK3α in sperm for male fertility. Biol Reprod. 2018 Jan 29. doi: 10.1093/biolre/ioy020.

• Freitas MJ, Vijayaraghavan S, Fardilha M. Signaling mechanisms in mammalian sperm motility. Biol Reprod. 2017 Jan 1;96(1):2-12. doi: 10.1095/biolreprod.116.144337. PubMed PMID: 28395326.

• Dudiki T, Kadunganattil S, Ferrara JK, Kline DW, Vijayaraghavan S. Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility. PLoS One. 2015 Nov 16;10(11):e0141961. doi: 10.1371/journal.pone.0141961. eCollection 2015. PubMed PMID: 26569399; PubMed Central PMCID: PMC4646675.

• Bhattacharjee R, Goswami S, Dudiki T, Popkie AP, Phiel CJ, Kline D, Vijayaraghavan S.  Targeted Disruption of Glycogen Synthase Kinase 3a (Gsk3a) Affects Sperm Motility Resulting in Male Infertility.  Biol Reprod. 2015 Jan 7. 114.124495. PMID: 25568307

 

• Sinha N, Puri P, Nairn AC, Vijayaraghavan S. Selective ablation of Ppp1cc gene in testicular germ cells causes oligo-teratozoospermia and infertility in mice.  Biol Reprod. 2013 Nov 27;89(5):128. PMID: 24089200

• Korrodi-Gregório L, Ferreira M, Vintém AP, Wu W, Muller T, Marcus K, Vijayaraghavan S, Brautigan DL, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.  BMC Cell Biol. 2013 Mar 18;14:15. doi: 10.1186/1471-2121-14-15.PMID: 23506001

• Fiedler SE, Dudiki T, Vijayaraghavan S, Carr DW. Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity. Biol Reprod. 2013 Feb 21;88(2):41. PMID: 23303679

 

• Sinha H, Pilder S, Vijayaraghavan S Significant Expression Levels of Transgenic PPP1CC2 in Testis and Sperm Are Required to Overcome the Male Infertility Phenotype of Ppp1cc Null Mice  2012 PLoS One ;7(10):e47623. doi: 10.1371/journal.pone.0047623. Epub 2012 Oct 17

• Puri P, Acker-Palmer A, Stahler R, Chen Y, Kline D, Vijayaraghavan S.  Identificaiton of testis 14-3-3 binding proteins by tandem affinity purification. Spermatogenesis. 2011 Oct;1(4):354-365.

 

• Soler DC, Kadunganattil S, Ramdas S, Myers K, Roca J, Slaughter T, Pilder SH, Vijayaraghavan S. Expression of transgenic PPP1CC2 in the testis of Ppp1cc-null mice rescues spermatid viability and spermiation but does not restore normal sperm tail ultrastructure, sperm motility, or fertility. Biol Reprod. 2009 Aug;81(2):343-52. Epub 2009 May 6.

• Cheng L, Pilder S, Nairn AC, Ramdas S, Vijayaraghavan S. PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related. PLoS One. 2009;4(3):e4861. Epub 2009 Mar 20

 

• Snow AJ, Puri P, Acker-Palmer A, Bouwmeester T, Vijayaraghavan S, Kline D. Phosphorylation-Dependent Interaction of Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein (YWHA) with PADI6 Following Oocyte Maturation in Mice. Biology of Reproduction 2008 May 7.

 

• Puri P, Myers K, Kline D, Vijayaraghavan S. Proteomic Analysis of Bovine Sperm YWHA Binding Partners Identify Proteins Involved in Signaling and Metabolism. Biology of  Reproduction. 2008 Aug 27.

• Chakrabarti R, Walker JM, Stewart DT, Trdan RJ, Vijayaraghavan S, Curole JP, Hoeh WR. 2006 Presence of a unique male-specific extension of C-terminus to the cytochrome c oxidase subunit II protein coded by the male-transmitted mitochondrial genome of Venustaconcha ellipsiformis (Bivalvia: Unionoidea). FEBS Letters  6;580(3):862-6
•  

• Bajpai M, Fiedler SE, Huang Z, Vijayaraghavan S, Olson GE, Livera G, Conti M, Carr DW. 2006 AKAP3 Selectively Binds PDE4A Isoforms in Bovine Spermatozoa. Biology of Reproduction Biol Reprod. 74(1):109-18.

• Huang Z, Somanath PR, Chakrabarti R, Eddy EM, Vijayaraghavan S. 2005 Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4. Biology of Reproduction 72:384-92. 

• Somanath PR, Jack SL, Vijayaraghavan S. 2004 Changes in sperm glycogen synthase kinase-3 serine phosphorylation and activity accompany motility initiation and stimulation. Jounal of Andrology 25:605-17.

• Myers K, Somanath PR, Berryman M, Vijayaraghavan S. 2004 Identification of chloride intracellular channel proteins in spermatozoa. FEBS Letters 566:136-40.

 

• Huang Z, Myers K, Khatra B, Vijayaraghavan S. 2004 Protein 14-3-3zeta binds to protein phosphatase PP1gamma2 in bovine epididymal spermatozoa. Biology of Reproduction 71:177-84. 

• Huang Z, Vijayaraghavan S. 2004 Increased phosphorylation of a distinct subcellular pool of protein phosphatase, PP1gamma2, during epididymal sperm maturation. Biology of Reproduction 70: 439-47. 

• Mishra S, Somanath PR, Huang Z, Vijayaraghavan S. 2003  Binding and inactivation of the germ cell-specific protein phosphatase PP1gamma2 by sds22 during epididymal sperm maturation. Biology of Reproduction 69:1572-9.

 

• Huang Z, Khatra B, Bollen M, Carr DW, Vijayaraghavan S. 2002 Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22.Biology of Reproduction 67:1936-42.

• Vijayaraghavan  S, Mojan J, Gray H, Khatra B and Carr DW 2000 A role for phosphorylation of glycogen synthase kinase-3a in sperm motility regulation.  Biology of Reproduction 62: 1647-1654

 

• Vijayaraghavan, S, Liberty, GA, Mohan J, Winfrey, VP, Olson, GE and Carr DW 1999 Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein Molecular Endocrinology 13:705-717.

• Smith, G.D., Wolfe, D.P., Trautman, K., and Vijayarghavan, S.  1999  Motility potential of Macaque epididymal sperm :  The role of protein phsophatase 1 and glycogen synthase kinase-3 activities.  Jounal of Andrology 20:47-53.

 

• Eaton GG, Worlein JM,  Kelley  ST, Vijayarghavan, S, Hess DL, Axthelm MK, Behtea CL 1999   Self-injurious behavior is decreased by cypoterone acetate in adult male rehesus (Macaca mulatta) Hormones and Behaviour 35:195-203.

• Vijayaraghavan, S, Olson, G.E., NagDas, S, Winfrey, V.P. and Carr, D. W. 1997 Subcellular localization  of the regulatory subunits of cAMP-dependent protein kinase in bovine spermatozoa. Biology of Reproduction  57:1517-1523 .

 

• Vijayaraghavan, S, Trautman, K., Goueli, S.A., and Carr, D. 1997 A tyrosine phosphorylated 55 kDa  motility protein is regulated by cAMP and calcium. Biology of Reproduction 56:1450-1457 .

• Vijayaraghavan, S, Goueli, S.A., Davey, M.P., and Carr, D.W. 1997 PKA anchoring, but not catalytic activity is required for sperm motility. Journal of Biological Chemistry 272:4747-4752.

 

• Vijayaraghavan, S, Trautman, K, Smith, G.D., Khatra, B., da Cruz e SIlva, E.F., and Greengard, P. 1996 Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity.  Biology of Reproduction 54:709-718.

• Smith, G.D., Wolf, D., Trautman, K, da Cruz e Silva, E.F., Greengard, P. and Vijayaraghavan, S.  1996 Primate sperm contain protein phosphatase 1 (PP1): a biochemical mediator of sperm motility. Biology of Reproduction 54:719-727.

 

• Vijayaraghavan, S, Trautman, K, Mishra, S.K. and Hermsmeyer, K.  1994 Evidence against an ATP-dependent calcium extrusion mechanism in bovine epididymal sperm.  Molecular  Reproduction and Development  38:326-333
• .

• Vijayaraghavan,  S.  and Hoskins,  D.D.  1990 Changes in the mitochondrial calcium influx and efflux properties are responsible for the decline in sperm calcium during epididymal maturation. Molecular Reproduction and Development 25: 178-186.

 

• Vijayaraghavan,  S.  and Hoskins,  D.D. 1989 Quantitation of bovine sperm cytoplasmic calcium with Quin 2 and Fura 2:  Evidence that external calcium does not have direct access to the sperm cytoplasm. Cell Calcium  10: 241-253.

• Vijayaraghavan,  S.,  Battacharya,  A.  and Hoskins,  D.D.  1989 Calcium uptake by bovine epididymal spermatozoa is regulated by the redox state of the mitochondrial pyridine nucleotides. Biology of Reproduction  40: 744-751.

 

• Vijayaraghavan,  S. and Hoskins,  D.D. 1988 A low molecular weight factor in bovine caudal epididymal fluid that stimulates calcium uptake in caput spermatozoa. Gamete Research  20:343-352.

• Vijayaraghavan,  S.  and Hoskins,  D.D.  1986 Regulation of bovine sperm motility and cyclic adenosine 3', 5'-monophosphate by adenosine and its analogues. Biology of Reproduction  34:468-477.

 

• Vijayaraghavan,  S.  and Hoskins,  D.D.  1985 Forskolin stimulates bovine epididymal sperm motility and cyclic AMP levels.  Journal of Cyclic Nucleotide and Protein Phosphorylation  Research  10:489-500.

• Vijayaraghavan,  S.,  Critchlow,  L.M.  and Hoskins,  D.D. 1985  Evidence for a role for cellular alkalinization in the cyclic adenosine 3', 5'-monophosphate-mediated initiation of motility in bovine caput spermatozoa.  Biology of  Reproduction  32:489-500.

 

• Hoskins,  D.D.,  Acott,  T.S.,  Critchlow,  L. and Vijayaraghavan,  S.  1983 Studies on the role of cyclic AMP and calcium in the development of bovine sperm motility.  Journal of  Submicroscopic  Cytology  15(1):21-27 (1983).

• Rivera,  E.M. and Vijayaraghavan,  S.   1982 Proliferation of ductal outgrowths by carcinogen-induced rat mammary tumors in gland-free mammary fat pads.  Journal  National  Cancer Institute  69:517-525.

 

• Rivera,  E.M. and Vijayaraghavan,  S.   1982 Rat mammary tumors from carcinogen-induced nodules and their responsiveness to ovariectomy.  European  Journal of Cancer and Clinical  Oncology  18: 53-58.

• Vijayaraghavan,  S.  and Rivera,  E.M. 1981 Preferential accumulation of iron in hyperplastic tissue of rat mammary gland.  Proceedings of the  Society of  Experimental  Biology and  Medicine  176:151-154.

 

• Shastri,  N.  Dubey,  S.K.,  Vijayaraghavan,  S.,  and Talwar,  G.P.  1978 Differential affinity of anti-Pr-b-hCG-TT antibodies for hCG and hLH.  Contraception 18:23-34.

                Book Chapters/ Invited Reviews

• Vijayaraghavan S, Chakrabarti R, Myers K. 2007 Regulation of sperm function by protein phosphatase PP1gamma2. Soc Reprod Fertil Suppl.; 63:111-21.

 

• Pilder SH, Lu J, Han Y, Hui L, Samant SA, Olugbemiga OO, Meyers KW, Cheng L, Vijayaraghavan S. 2007 The molecular basis of "curlicue": a sperm motility abnormality linked to the sterility of t haplotype homozygous male mice. Soc Reprod Fertil Suppl. 63:123-33.

• Chakrabarti R, Cheng L, Puri P, Soler D, Vijayaraghavan S.2007  Protein phosphatase PP1 gamma 2 in sperm morphogenesis and epididymal initiation of sperm motility. Asian J Androl.  9(4):445-52.

 

• Viijayaraghavan S  2003 Sperm Motility - Patterns and Regulation in Introduction to Mannalian Reproduction  Ed:  Tulsiani D, Kulver Academic Publishers (Boston)

• Hoskins,  D. D. and Vijayaraghavan,  S.   1991 A New Theory  on the Epididymal Development of Sperm Motility:  Interrelationships among adenosine,  calcium and cyclic AMP. Comparative Spermatology 75: 479-483.

 

• Hoskins,  D.D. and Vijayaraghavan,  S. 1990 A New View on the Acquisition of Sperm Motility During epididymal Transit.  In:  Controls of Sperm Motility:  Biological and Clinical Aspects (C.  Gagnon,  ed.).  Boca Raton,  Ann Arbor,  Boston:  CRC Press,  Chapter 4,  pp.  53-62.

• Gaur,  R.D.,  Vijayaraghavan,  S.  and Talwar,  G.P.  1979  Cross species action of a human seminal plasma factor on motility and survival of spermatozoa.  In:  Recent Advances in Reproduction and Regulation of Fertility.  Talwar,  G.P.  ed.,  Elsevier/North Holland Biomedical Press,   301.

 

• Gaur,  R. D.,  Vijayaraghavan,  S and Talwar,  G.P.  Fertilization promoting factor from human seminal plasma  In:  Regulation of Growth and Differentiated Function of Eukaroyotic Cells.  Talwar,  G.P.,  ed.  Raven Press,  New York 515 (1977).