Laboratory of Neuroendocrinology and Behavior

  Heather K. Caldwell, Ph.D.

 

 

 

 

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Publications

Papers

1.      H.K. Caldwell, E.A. Aulino, K.M. Rodriguez, S.K. Witchey, A.M. Yaw. (2017) Social context, stress, neuropsychiatric disorders, and the vasopressin 1b receptor. Front Neurosci.,11: 567. Review.

2.      H.K. Caldwell. (2017) Oxytocin and vasopressin: powerful regulators of social behavior. Neuroscientist, [epub ahead of print]. Review.

3.      H.K. Caldwell. (2017) Who are you and where am I? New insights into how animals determine their social context. Endocrinology, 158(2):233-234. Invited Commentary.

4.      S.K. Witchey, E.L. Stevenson, H.K. Caldwell. (2016) Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice. BMC Neurosci., 17(1):75.

5.      J.C. Morales-Medina, T. Iannitti, A. Freeman, H.K. Caldwell (2016) The olfactory bulbectomized rat as a model of depression: the hippocampal pathway. Behav Brain Res., 317:562-575.  Review.

6.      H.K. Caldwell, E.A. Aulino, A.R. Freeman, T.V. Miller, S.K. Witchey. (2016) Oxytocin and behavior: Lessons from knockout mice. Dev Neurobiol., 77(2): 190-201. Review.

7.      S. Tamborski, E.M. Mintz, H.K. Caldwell (2016) Sex Differences in the embryonic development of the central oxytocin system in mice.  Neuroendocrinol. 2016 Apr;28(4).

8.      M.E. Rich and H.K. Caldwell (2015) A role for oxytocin in the etiology and treatment of schizophrenia. Frontiers in Endocrinology, Neuroendocrine Science: 6:90.

9.      T.V. Miller and H.K. Caldwell (2015) Oxytocin during development: possible organizational effects on behavior. Frontiers in Endocrinology, Neuroendocrine Science: 6:76.

10.  E.L. Stevenson and H.K. Caldwell. (2014) Lesions to the CA2 region of the hippocampus impair social memory in mice. Eur J Neurosci. 40(9): 3294-301

11.  M.E. Rich, E.J. deCárdenas, H-J. Lee, and H.K. Caldwell (2014) Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice. PLoS ONE: 9(6): e98839.

  1. M.B. Dhakar, M.E. Rich, E.L. Reno, H-J. Lee, and H.K. Caldwell (2012) Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor. Hormones and Behavior, 62(1): 86-92.
  2. E.L. Stevenson and H.K. Caldwell (2012) The vasopressin 1b receptor and the neural regulation of social behavior. Hormones and Behavior, 61(3): 277-282.
  3. A.H. Macbeth*, J.E. Stepp, H-J. Lee, W.S. Young, III, H.K. Caldwell* (2010) Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females. Behavioral Neuroscience, 124: 677-685. (*authors contributed equally)
  4. H.K. Caldwell, O.E. Dike, Stevenson, E.L., K. Storck, W.S. Young, III (2010) Social dominance in male vasopressin 1b receptor knockout mice. Hormones and Behavior, 58(2): 257-263.
  5. H.K. Caldwell, W. S. Young, III (2009) Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more “wild” background. Physiology & Behavior, 97: 131
  6. H.K. Caldwell, S.L. Stephens, W.S. Young, III (2009) Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice. Molecular Psychiatry, 14: 190-196.
  7. H-J. Lee, H.K. Caldwell, A.H. Macbeth, S.G. Tolu, W.S. Young, III (2008) A conditional knockout mouse line of the oxytocin receptor. Endocrinology, 149 (7): 3256-3263.
  8. H.K. Caldwell, D.A. Smith, and H.E. Albers (2008) Photoperiodic mechanisms controlling scent marking: Interactions of vasopressin and gonadal steroids. European Journal of Neuroscience, 27: 1189-1196.
  9. M.L. Scattoni, H. McFarlane, V. Zhodzishsky, H.K. Caldwell, W.S. Young, L. Ricceri, J.N. Crawley (2008) Reduced ultrasonic vocalization in vasopressin 1b knockout mice. Behavioural Brain Research, 187 (2): 371-378.
  10. S.R. Wersinger, J.L. Temple, H.K. Caldwell, W.S. Young, III (2008) Inactivation of the oxytocin and the vasopressin 1b receptor genes, but not the vasopressin 1a receptor gene, impair male-induced pregnancy block. Endocrinology, 149(1): 116-121.
  11. H.K. Caldwell, H-J. Lee*, A.H. Macbeth*, W.S. Young, III (2008) Vasopressin: Behavioral roles for an “original” neuropeptide. Progress in Neurobiology, 84(1): 1-24. (*authors contributed equally)
  12. M. Yang, M.L. Scattoni, V. Zhodzishsky, T. Chen, H.K. Caldwell, W.S. Young, H.G. McFarlane, J.N. Crawley (2007) Similar social approach behaviors in BTBT T+ tf/J and C57BL/6J strains and vasopressin 1b receptor knockout mice tested on conventional versus reverse lighting cycles, and in replications across cohorts of vasopressin 1b mutant mice. Frontiers in Behavioral Neuroscience, 1(1):Epub.
  13. J.N. Crawley, T. Chen, A.Puri, T.L. Sullivan, J. M. Hill, N.B. Young, J.J. Nadler, S. Moy, L.J. Young, H.K. Caldwell, W.S. Young, III.  (2007) Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in two laboratory environments. Neuropeptides, 41(3): 145-163.
  14. S.R. Wersinger, H.K. Caldwell, M. Christiansen, and W.S.Young, III (2007) Disruption of the vasopressin 1b receptor gene impairs the attack component of social behavior in mice. Genes, Brain and Behavior, 6(7): 653-660.
  15. S.R. Wersinger*, H.K. Caldwell*, L. Martinez, P. Gold, Shaung-Bao, W.S. Young, III.  (2007) Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes, Brain and Behavior, 6 (6): 540-551. (*authors contributed equally)
  16. H.K. Caldwell, J. Stewart, L. Wiedholz, R. Millstein, A. Iacangelo, A. Holmes, W.S. Young, III, and S.R. Wersinger. (2006) The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors.  Neuropeptides, 40 (4): 325-337.  
  17. H.K. Caldwell and H.E. Albers (2004) Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters. Hormones and Behavior, 46(4): 444-449.
  18. H.K. Caldwell and H.E. Albers (2004) Photoperiodic regulation of vasopressin receptor binding in female Syrian hamsters. Brain Research, 1002: 134-139.
  19. H.K. Caldwell and H.E. Albers (2003) Short-photoperiod exposure reduces vasopressin (V1a) receptor binding but not AVP-induced flank marking in male Syrian hamsters.  Journal of Neuroendocrinology, 15(10): 971-977.
  20. H.K. Caldwell and H.E. Albers (2002) The effects of 5-HT agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters.  Hormones and Behavior 42: 78-84.
  21. H.K. Caldwell and J.J. Lepri (2002) Disruption of the fifth melanocortin receptor alters the urinary excretion of aggression-modifying pheromones in male house mice. Chemical Senses, 27: 91-94.
  22. D.J. Fickbohm, C. Lynn-Bullock, N. Spitzer, H. Caldwell, P.Katz.  (2001) Localization and quantification of 5-hydroxytryptophan and serotonin in the central nervous systems of Tritonia and Aplysia.  Journal of Comparative Neurology 437: 91-105.

 

Book Chapters

1.      J.C. Morales-Medina, S.K. Witchey, and H.K. Caldwell (2016) The role of vasopressin in anxiety and depression. In “Melatonin and Neuroprotective Agents in Neuropsychiatric Disorders” Landes Bioscience and Springer Science, Texas.

2.      H.K. Caldwell and H.E. Albers (2016) Oxytocin, vasopressin, and the motivational forces that drive social behaviors. E. Simpson and P. Balsom (eds). Curr Top Behav Neurosci.;27:51-103. Springer Science, Texas.

3.      M.B. Dhakar*, E.L. Stevenson*, and H.K. Caldwell (2013) Oxytocin, vasopressin and their interplay with gonadal steroids pp. 3-36. E. Choleris, D. Pfaff, and M. Kavaliers (eds). In “Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior” Cambridge University Press. (* authors contributed equally)

4.      H.K. Caldwell (2012) The Neurobiology of Sociability. Pp. 187-205. Carlos Lopez-Larrea (ed). In “Sensing in Nature” Landes Bioscience and Springer Science, Texas.

5.      H.K. Caldwell, S.R. Wersinger, W.S. Young, III (2008) The Role of the Vasopressin 1b Receptor in Aggression and Other Social Behaviors. Progress in Brain Research. 170: 65-72.

6.      H-J. Lee, H.K. Caldwell, A.H. Macbeth, W.S. Young, III (2008). Behavioral Studies Using Temporal and Spatial Inactivation of the Oxytocin Receptor. Progress in Brain Research. 170: 73-77.

7.      H.K. Caldwell and W.S. Young, III (2006) Oxytocin and Vasopressin: Genetics and Behavioral Implications, pp. 573-607. Abel Lajtha (ed). In “Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition: Volume 9: Neuroactive Proteins and Peptides (Ramon Lim (ed))” Springer, New York.

8.      H.K. Caldwell, L. Wang, and J.J. Lepri. (2001) Simplified tests of aggression chemosignals in male house mice suggest that a melanocortin-dependent product of the preputial gland reduces attacks, pp. 445-450.  A. Marchhlewska-Koj, J. Lepri, and D. Muller-Schwarze (eds). “Chemical Signals in Vertebrates IX,” Kluwer Academic/Plenum Publishers, New York.